From listmaster animalgenome.org Tue Feb 17 21:50:24 2026
Subject: Re: Question on Parentage analysis
From: "Jesse Hoff" <jesse.hoffgmail.com>
To: Members of AnGenMap <angenmapanimalgenome.org>
Date: Tue, 17 Feb 2026 21:50:24 -0600
The underlying strs and the assay readout robustness are both somewhat
likely to mutate or drift
If you're dying to know and money is no object some long read data will
characterize what's changed in this offspring.
However, it seems pretty apparent that the snp data is right. If you need
even more validation of the parentage call and don't care about the strs
biology, get some whole genome sequencing on each of them.
On Tue, Feb 17, 2026, 6:11=E2=80=AFPM Robin Everts <revertsetalondx.com> w=
rote:
> Hello all:
>
> Hope this is the right place to ask this question, if not, my apologies.
>
> I have a question for which I'd like some input.
>
> We recently tested an animal with 17 STR Parentage markers and it was found
> to contain 2 allelic discordant outcomes vs the alleged father and mother,
> one allele in 2 different markers. Another lab had the exact same STR
> results as we did.
>
> We also ran 400+ ISAG Parentage SNP markers and found 0 discordant outcomes
> vs both parents. We passed the ISAG parentage comparison test 2025 with a
> 100% correct score.
>
> 1) What do you think happened here
> 2) Are SNPs better than STRs? Or other way around?
> 3) How should this be considered with respect to real parent/offspring
> situation?
>
> Sincerely,
>
> Robin
> revertsetalondx.com
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