QTL Course: June 2000 Belo Horizonte - Brasil

IDENTIFYING AND INCORPORATING GENETIC MARKERS AND MAJOR GENES
IN ANIMAL BREEDING PROGRAMS
Brian Kinghorn & Julius van der Werf
University of New England, Armidale, Australia

(All chapters and exercises are available in PDF files, you need Acrobat Reader to view them)

Table of Contents
Chapter Title Author Page
Cover Page
Part I: Introduction and building blocks
1 Overview of animal breeding and the role of QTL Julius van der Werf 1
2 The building blocks of quantitative genetics. Brian Kinghorn 9
3 Calculation of genotype probabilities from phenotypic data or DNA tests Brian Kinghorn 23
4 Introduction to some aspects of Molecular Genetics Julius van der Werf 35
Part II Linkage analysis and gene mapping
5 Basics of linkage and mapping Julius van der Werf 45
Part III Detection and mapping of QTL
6 Principles of estimating QTL effects (single markers) Brian Kinghorn 55
7 Use of multiple markers: interval mapping Julius van der Werf 61
8 QTL detection in designed experiments and in outbred populations Brian Kinghorn 71
9 Methods for QTL analysis Julius van der Werf 79
10 Genetic models for detecting multiple QTL Julius van der Werf 91
11 Multiple trait models for QTL analysis Brian Kinghorn 99
12 Experimental strategies for QTL detection Jack Dekkers 105
13 Fine mapping and IBD mapping Julius van der Werf 109
14 Positional cloning, candidate genes, and comparative mapping Brian Kinghorn 115
Part IV Marker Assisted Selection
15 Basics of marker assisted selection Julius van der Werf 119
16 Implementation of direct and indirect markers Brian Kinghorn 129
17 Genetic evaluation at individual QTL Julius van der Werf 139
18 Examples of marker assisted selection Julius van der Werf 147
19 Targeting QTL using mate selection Brian Kinghorn 153
Exercises
  • 1-1 -Excercise 1
  • 1-2 -Excercise 2
  • 2-2 -Excercise 3
  • 3-1 -Excercise 4
  • 3-2 -Excercise 5
  • 5-1 -Excercise 6
  • Appendix:
    Excel spreadsheet on QTL mapping

    • The original sources of the materials on this page is provided by Julius van der Werf (jvanderw@metz.une.edu.au ).
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