PPT Slide
Hypothesis Testing Computing Critical Values (CV)
- Adjust standard CV based on equation of Lander&Kruglyak (1995)
- Assumes high-density marker map
- Develop empirical Critical Values
- Simulate data under the Null Hypothesis (=no QTL)
- Compute test statistic (F-test / LR)
- Replicate many times
- Determine 95% percentile level of test statistic (for 5% test)
- Simulation of data under Null Hypothesis
- Complete simulation of marker genotypes and phenotypes based on assumed genetic model (polygenic with no QTL - requires knowledge of genetic parameters)
- Permutation test (Churchil and Doerge, 1994, Genetics 138:963)