PPT Slide

Yi = phenotype individual i

XMi = indicator for marker M from F1 (0/1)

XNi = indicator for marker N from F1 (0/1)

Yi = m + bMXMi + bNXNi +ei bM = regression coeff. for marker M

bN = regression coeff. of marker N

ei = random residual for individual i

E(bM) = a [r2(1-r2)(1-2r1)/q(1-q)]

E(bN) = a [r1(1-r1)(1-2r2)/q(1-q)]

q=r1+r2-2r1r2 (no interference)

4 bN q (1-q) 0.5

r1 = 1/2{1-[1- ] }

bN+bM (1-2q)

[bN+(1-2q)bM][bM+(1-2q)bN]

a2 =

(1-2q)

Regression on Flanking Markers

To estimate QTL position and effect separately

Backcross

Whittaker et al. (1996)

Heredity 77: 23