A Primer on Molecular Genetics

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This material was by Denise Casey (Human Genome Management Information System at the Oak Ridge National Laboratory)

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• Introduction
  • DNA
  • Genes
  • Chromosomes
  
  
• Mapping and Sequencing the Human Genome
  
  • Mapping Strategies
  • Genetic Linkage Maps
  • Physical Maps
    • Low-Resolution Physical Mapping
      • Chromosomal map
      • cDNA map
    • High-Resolution Physical Mapping
      • Macrorestriction maps: Top-down mapping
      • Contig maps: Bottom-up mapping
  • Sequencing Technologies
    • Current Sequencing Technologies
    • Sequencing Technologies Under Development
    • Partial Sequencing to Facilitate Mapping, Gene Identification
  • End Games: Completing Maps and Sequences; Finding Specific Genes

• Model Organism Research

• Informatics: Data Collection and Interpretation
  • Collecting and Storing Data
  • Interpreting Data
  • Mapping Databases
  • Sequence Databases
    • Nucleic Acids (DNA and RNA)
    • Proteins

• Impact of the Human Genome Project

• Glossary

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